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Innate immune responses in RNA viral infection
Qian Xu, Yuting Tang, Gang Huang
《医学前沿(英文)》 2021年 第15卷 第3期 页码 333-346 doi: 10.1007/s11684-020-0776-7
关键词: innate immune viral infection intercellular signaling metabolic changes epigenetic changes
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities. It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network. Much is known about ethylene, one of the most important metabolites promoting the ripening of climacteric fruits. However, the dynamic interplay between phytohormones also plays an important part. Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening. Here, we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.
关键词: climacteric fruit ripening / phytohormones / TFs / epigenetic modifications
Yinglin JI, Mingyang XU, Aide WANG
《农业科学与工程前沿(英文)》 页码 314-334 doi: 10.15302/J-FASE-2021386
关键词: climacteric fruit ripening phytohormones TFs epigenetic modifications
The value of epigenetic markers in esophageal cancer
Xiao-Mei ZHANG, Ming-Zhou GUO,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 378-384 doi: 10.1007/s11684-010-0230-3
关键词: epigenetics DNA methylation esophageal cancer dysplasia
《医学前沿(英文)》 2022年 第16卷 第2期 页码 176-184 doi: 10.1007/s11684-021-0885-y
关键词: small noncoding RNAs epigenetic inheritance paternal intergenerational inherence extracellular vesicles
Cellular changes in bronchoalveolar lavage fluid in hyperoxia-induced lung injury
HE Xinbiao, ZHAO Wei
《医学前沿(英文)》 2008年 第2卷 第4期 页码 370-373 doi: 10.1007/s11684-008-0071-5
Elucidate long-term changes of ozone in Shanghai based on an integrated machine learning method
《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1738-5
● A novel integrated machine learning method to analyze O3 changes is proposed.
From gut changes to type 2 diabetes remission after gastric bypass surgeries
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 191-200 doi: 10.1007/s11684-013-0258-2
Increasing evidence suggests that the gut may influence the host’s metabolism and ultimately change the outcomes of type 2 diabetes mellitus (T2DM). We review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgery, and discuss the potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changes, altered gut cells, and gut hormone modulation. However, the exact changes and their relative importance in the metabolic improvements after gastric bypass surgery remain to be further clarified. Elucidating the precise metabolic mechanisms of T2DM resolution after bypass surgery will help to reveal the molecular mechanisms of pathogenesis, and facilitate the development of novel diagnoses and preventative interventions for this common disease.
关键词: gastric bypass T2DM gut
FU Xiaoguo, CHEN Hongzhang, LI Hongqiang, MA Runyu
《化学科学与工程前沿(英文)》 2007年 第1卷 第2期 页码 113-117 doi: 10.1007/s11705-007-0021-9
Qiang Li, Xiong Xu, Yaoyao Fang, Ruiyang Xiao, Donghong Wang, Wenjue Zhong
《环境科学与工程前沿(英文)》 2018年 第12卷 第6期 doi: 10.1007/s11783-018-1054-7
The current situation of typical organics in the sediments around Beijing was unclear. 56 kinds of typical toxic organics were detected in this article. Historical data was compared with the data in this study. The change of different organics in the sediments around Beijing was concluded.
关键词: Organic compounds Endocrine disrupters Sediments Concentration Temporal changes
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 231-241 doi: 10.1007/s11684-013-0253-7
Hepatocellular carcinoma (HCC) development is characterized by the presence of epigenetic alterations, including promoter DNA hypermethylation and post-translational modifications of histone, which profoundly affect expression of a wide repertoire of genes critical for cancer development. Emerging data suggest that deregulation of polycomb group (PcG) proteins, which are key chromatin modifiers repressing gene transcription during developmental stage, plays a causative role in oncogenesis. PcG proteins assemble into polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2) to impose the histone H3 lysine 27 trimethylation (H3K27me3) modification for repression. In this review, we will first recapitulate the mechanisms of two key epigenetic pathways: DNA methylation and histone modifications. Specifically, we will focus our discussion on the molecular roles of PcG proteins. Next, we will highlight recent findings on PcG proteins, their clinicopathological implication and their downstream molecular consequence in hepatocarcinogenesis. Last but not least, we will consider the therapeutic potential of targeting enhancer of zeste homolog 2 (EZH2) as a possible treatment for HCC. Improving our understanding on the roles of PcG proteins in hepatocarcinogenesis can benefit the development of epigenetic-based therapy.
关键词: liver cancer epigenetics histone modifications polycomb group proteins enhancer of zeste homolog 2 (EZH2)
《环境科学与工程前沿(英文)》 2022年 第16卷 第2期 doi: 10.1007/s11783-021-1458-7
•Tryptophan protein, and aromatic protein I/II were the key identified proteins.
关键词: Sludge pretreatments Dissolved organic nitrogen Proteins Amino acids Structural equation model Metagenomic sequencing analysis.
GUO Tiecheng, CAO Xuebing, XIA Limin
《医学前沿(英文)》 2008年 第2卷 第4期 页码 406-409 doi: 10.1007/s11684-008-0078-y
《医学前沿(英文)》 2022年 第16卷 第3期 页码 429-441 doi: 10.1007/s11684-021-0842-9
关键词: ischemic stroke microenvironment induced pluripotent stem cells (iPSCs) positron emission tomography (PET) quantitative proteomics
Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)
《环境科学与工程前沿(英文)》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1569-9
● Fe3O4 NPs increased the biomass and chlorophyll content of hemp clones.
关键词: Fe3O4 nanoparticle Hemp Growth enhancement THC Metabolite
标题 作者 时间 类型 操作
RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC
期刊论文
RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC
Yinglin JI, Mingyang XU, Aide WANG
期刊论文
environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic
期刊论文
Cellular changes in bronchoalveolar lavage fluid in hyperoxia-induced lung injury
HE Xinbiao, ZHAO Wei
期刊论文
Elucidate long-term changes of ozone in Shanghai based on an integrated machine learning method
期刊论文
Study on microbial protein and the mechanism of solid-state fermentation with periodical dynamic changes
FU Xiaoguo, CHEN Hongzhang, LI Hongqiang, MA Runyu
期刊论文
The temporal changes of the concentration level of typical toxic organics in the river sediments around
Qiang Li, Xiong Xu, Yaoyao Fang, Ruiyang Xiao, Donghong Wang, Wenjue Zhong
期刊论文
Anaerobic digestion of sludge by different pretreatments: Changes of amino acids and microbial community
期刊论文
Repetitive transcranial magnetic stimulation causes significant changes of chemical substances in the
GUO Tiecheng, CAO Xuebing, XIA Limin
期刊论文
Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation
期刊论文